XSelect CSH C18 柱是以C18为骨架，CSH C18具有宽泛的选择性。CSH技术能改善峰形，提高载液量。即使装填在低分散性的柱体内，
2010年，沃特世推出了新型表面带电杂化颗粒(CSH™)技术，为杂化颗粒表面赋予少量正电荷。利用这一技术可以使用低离子强度的流动相(如0.1%甲酸体系)分析碱性化合物，而仍能获得卓越的峰形与载量。CSH技术还允许使用甲酸来替代TFA等离子对试剂，而仍保持带电分析物的良好峰形，对于质谱分析尤为有利。
XSelect CSH C18 柱在低离子强度流动相条件下(如0.1%甲酸体系)因载量所导致的峰形差问题。因带有严格控制下的、低水平的正表面电荷，该柱为碱性化合物提供的峰行无需使用离子对试剂。
按美国药典方法及中国药典方法检测紫杉醇药物
紫杉醇（Paclitaxel）最初是从红豆杉科红豆杉属（Taxus）植物 的树皮中提取得到的二萜类化合物，具有独特抗癌活性，曾 被美国国立癌症研究所认为是近15-20年来肿瘤化疗的最重 要的进展。紫杉醇注射液功效主治卵巢癌和乳腺癌及NSCLC 的一线和二线治疗。头颈癌、食管癌，精原细胞瘤，复发非何 金氏淋巴瘤等。因紫杉醇抗癌疗效明确，临床应用市场容量 大，原料药与制剂药生产需求持续，对于紫杉醇的新剂型研 究以及对紫杉醇同系物的新药开发也一直在持续进行中。 美国药典方法规定使用L43全氟苯基柱对紫杉醇[1]以及紫杉 醇注射液进行含量测定，
系统方法条件如下： 流动相：水-乙腈 11:9（即 55:45），如需要时可适当调整比例。 洗脱：等度，1.5mL/min[1] 色谱柱：5µm, 4.6[1]或4.0[2] mmID x 250mmL，L43（即：PFP，全氟苯基） 检测：UV 227nm 要求：拖尾因子0.7-1.3范围内[1]；紫杉醇峰的保留时间在6.0- 10.0min范围内[2] 美国药典指导性通则USP Chromatography <621>对色谱方法进行定义并制定了方法实施的指导原则，其中也规定了色谱方 法的调整范围，如果检测方法调整在此范围内，即视为仍遵 循原方法的法规要求，只要能够满足系统适应性要求，就无 需进行方法再验证。液相色谱方法的调整范围包括不仅限 于如下： - 色谱柱粒径可减小（但减小程度最多为50%） - 柱长度可调整±70% - 流速可调整±50% 使用沃特世最新产品XSelect™ HSS PFP色谱柱(3.5µm, 4.6x150mm，PN186005862)，流速1mL/min，对紫杉醇混标进行 分离，可达到系统适应性要求，且峰形良好，分离优异。柱 规格与流速的改变在通则<621>的限制范围之内，因此方法仍具有法规依从性。
品名 | 编号 |
XSelect CSH C18 Column, 130Å, 3.5 µm, 2.1 mm X 50 mm, 1/pkg | 186005255 |
XSelect CSH C18 Column, 130Å, 3.5 µm, 2.1 mm X 100 mm, 1/pkg | 186005256 |
XSelect CSH C18 Column, 130Å, 3.5 µm, 2.1 mm X 150 mm, 1/pkg | 186005257 |
XSelect CSH C18 Column, 130Å, 3.5 µm, 1 mm X 150 mm, 1/pkg | 186005251 |
XSelect CSH C18 Column, 130Å, 3.5 µm, 2.1 mm X 20 mm, 1/pkg | 186005253 |
XSelect CSH C18 Column, 130Å, 3.5 µm, 2.1 mm X 30 mm, 1/pkg | 186005254 |
XSelect CSH C18 Column, 130Å, 3.5 µm, 1 mm X 100 mm, 1/pkg | 186005250 |
XSelect CSH C18 Column, 130Å, 3.5 µm, 2.1 mm X 75 mm, 1/pkg | 186005644 |
XSelect CSH C18 Column, 130Å, 3.5 µm, 4.6 mm X 150 mm, 1/pkg | 186005270 |
XSelect CSH C18 Column, 130Å, 3.5 µm, 3 mm X 75 mm, 1/pkg | 186005647 |
XSelect CSH C18 Column, 130Å, 3.5 µm, 3 mm X 20 mm, 1/pkg | 186005259 |
XSelect CSH C18 Column, 130Å, 3.5 µm, 4.6 mm X 20 mm, 1/pkg | 186005265 |
XSelect CSH C18 Column, 130Å, 3.5 µm, 3 mm X 100 mm, 1/pkg | 186005262 |
XSelect CSH C18 Column, 130Å, 3.5 µm, 3 mm X 150 mm, 1/pkg | 186005263 |
XSelect CSH C18 Column, 130Å, 3.5 µm, 4.6 mm X 75 mm, 1/pkg | 186005268 |
XSelect CSH C18 Column, 130Å, 3.5 µm, 4.6 mm X 100 mm, 1/pkg | 186005269 |
XSelect CSH C18 Column, 130Å, 3.5 µm, 4.6 mm X 30 mm, 1/pkg | 186005266 |
XSelect CSH C18 Column, 130Å, 3.5 µm, 4.6 mm X 50 mm, 1/pkg | 186005267 |
XSelect CSH C18 Column, 130Å, 3.5 µm, 3 mm X 30 mm, 1/pkg | 186005260 |
XSelect CSH C18 Column, 130Å, 3.5 µm, 3 mm X 50 mm, 1/pkg | 186005261 |
XSelect CSH C18 Column, 130Å, 5 µm, 2.1 mm X 30 mm, 1/pkg | 186005273 |
XSelect CSH C18 Column, 130Å, 5 µm, 2.1 mm X 50 mm, 1/pkg | 186005274 |
XSelect CSH C18 Column, 130Å, 5 µm, 2.1 mm X 100 mm, 1/pkg | 186005275 |
XSelect CSH C18 Column, 130Å, 5 µm, 2.1 mm X 150 mm, 1/pkg | 186005276 |
XSelect CSH C18 Column, 130Å, 5 µm, 3 mm X 30 mm, 1/pkg | 186005279 |
XSelect CSH C18 Column, 130Å, 5 µm, 4.6 mm X 150 mm, 1/pkg | 186005290 |
XSelect CSH C18 Column, 130Å, 5 µm, 4.6 mm X 250 mm, 1/pkg | 186005291 |
XSelect CSH C18 Column, 130Å, 5 µm, 2.1 mm X 20 mm, 1/pkg | 186005272 |
XSelect CSH C18 Column, 130Å, 5 µm, 4.6 mm X 20 mm, 1/pkg | 186005284 |
XSelect CSH C18 Column, 130Å, 5 µm, 4.6 mm X 30 mm, 1/pkg | 186005286 |
XSelect CSH C18 Column, 130Å, 5 µm, 4.6 mm X 50 mm, 1/pkg | 186005287 |
XSelect CSH C18 Column, 130Å, 5 µm, 4.6 mm X 75 mm, 1/pkg | 186005288 |
XSelect CSH C18 Column, 130Å, 5 µm, 4.6 mm X 100 mm, 1/pkg | 186005289 |
XSelect CSH C18 Method Validation Kit, 130Å, 2.5 µm, 4.6 mm X 100 mm, 3/pkg | 186006238 |
XSelect CSH C18 Column, 130Å, 5 µm, 3 mm X 50 mm, 1/pkg | 186005280 |
XSelect CSH C18 Column, 130Å, 5 µm, 3 mm X 100 mm, 1/pkg | 186005281 |
XSelect CSH C18 Column, 130Å, 5 µm, 3 mm X 150 mm, 1/pkg | 186005282 |
XSelect CSH C18 Column, 130Å, 5 µm, 3 mm X 250 mm, 1/pkg | 186005283 |
XSelect CSH C18 Method Validation Kit, 130Å, 2.5 µm, 2.1 mm X 50 mm, 3/pkg | 186006233 |
XSelect CSH C18 Method Validation Kit, 130Å, 2.5 µm, 2.1 mm X 150 mm, 3/pkg | 186006785 |
XSelect CSH C18 Method Validation Kit, 130Å, 2.5 µm, 3 mm X 150 mm, 3/pkg | 186006786 |
XSelect CSH C18 Method Validation Kit, 130Å, 2.5 µm, 4.6 mm X 150 mm, 3/pkg | 186006787 |
XSelect CSH C18 Method Validation Kit, 130Å, 2.5 µm, 3 mm X 100 mm, 3/pkg | 186006236 |
XSelect CSH C18 Method Validation Kit, 130Å, 2.5 µm, 4.6 mm X 50 mm, 3/pkg | 186006237 |
XSelect CSH C18 Method Validation Kit, 130Å, 2.5 µm, 2.1 mm X 100 mm, 3/pkg | 186006234 |
XSelect CSH C18 Method Validation Kit, 130Å, 5 µm, 3 mm X 150 mm, 3/pkg | 186005545 |
XSelect CSH C18 Method Validation Kit, 130Å, 5 µm, 4.6 mm X 100 mm, 3/pkg | 186005546 |
XSelect CSH C18 Method Validation Kit, 130Å, 5 µm, 4.6 mm X 150 mm, 3/pkg | 186005547 |
XSelect CSH C18 Method Validation Kit, 130Å, 5 µm, 4.6 mm X 250 mm, 3/pkg | 186005548 |
XSelect CSH C18 OBD Prep Column, 130Å, 5 µm, 19 mm X 100 mm, 1/pkg | 186005421 |
XSelect CSH C18 Method Validation Kit, 130Å, 3.5 µm, 3 mm X 150 mm, 3/pkg | 186005540 |
XSelect CSH C18 Method Validation Kit, 130Å, 3.5 µm, 4.6 mm X 150 mm, 3/pkg | 186005542 |
XSelect CSH C18 Method Validation Kit, 130Å, 3.5 µm, 4.6 mm X 100 mm, 3/pkg | 186005541 |
XSelect CSH C18 Method Validation Kit, 130Å, 5 µm, 2.1 mm X 150 mm, 3/pkg | 186005543 |
XSelect CSH C18 OBD Prep Column, 130Å, 10 µm, 30 mm X 50 mm, 1/pkg | 186007296 |
XSelect CSH C18 OBD Prep Column, 130Å, 10 µm, 19 mm X 150 mm, 1/pkg | 186007293 |
XSelect CSH C18 Method Validation Kit, 130Å, 3.5 µm, 2.1 mm X 100 mm, 3/pkg | 186005538 |
XSelect CSH C18 OBD Prep Column, 130Å, 10 µm, 19 mm X 250 mm, 1/pkg | 186007294 |
XSelect CSH C18 Method Validation Kit, 130Å, 3.5 µm, 3 mm X 100 mm, 3/pkg | 186005539 |
XSelect CSH C18 OBD Prep Column, 130Å, 10 µm, 19 mm X 50 mm, 1/pkg | 186007291 |
XSelect CSH C18 OBD Prep Column, 130Å, 10 µm, 19 mm X 100 mm, 1/pkg | 186007292 |
XSelect CSH C18 OBD Prep Column, 130Å, 10 µm, 30 mm X 150 mm, 1/pkg | 186007299 |
XSelect CSH C18 OBD Prep Column, 130Å, 10 µm, 30 mm X 75 mm, 1/pkg | 186007297 |
XSelect CSH C18 OBD Prep Column, 130Å, 10 µm, 30 mm X 100 mm, 1/pkg | 186007298 |
XSelect CSH C18 Method Validation Kit, XP Column, 130Å, 2.5 µm, 3 mm X 50 mm, 3/pkg | 186006235 |
XSelect CSH C18 OBD Prep Column, 130Å, 10 µm, 50 mm X 150 mm, 1/pkg | 186007303 |
XSelect CSH C18 OBD Prep Column, 130Å, 10 µm, 50 mm X 250 mm, 1/pkg | 186007304 |
XSelect CSH C18 OBD Prep Column, 130Å, 10 µm, 50 mm X 50 mm, 1/pkg | 186007301 |
XSelect CSH C18 OBD Prep Column, 130Å, 10 µm, 50 mm X 100 mm, 1/pkg | 186007302 |
XSelect CSH C18 OBD Prep Column, 130Å, 10 µm, 30 mm X 250 mm, 1/pkg | 186007300 |
相关产品
即问即答，我们在线为您服务！
