XSelect HSS C18 SB Column
广泛的选择性,即使装填在低分散性的柱体内,优越的分离效果、稳定性。
应用领域
制药、生物、化工、食品、环境、缉毒

XSelect HSS C18 SB 柱是通用性C18色谱柱,用于提供对碱性分析物的优异峰形、提高保留(相对于BEH C18柱),以及在低pH条件下的较长柱寿命。HSS C18柱所表现出的选择性与保留性与大多数现代全封端的硅胶C18色谱柱色谱行为较为相近。

Development and validation of new RP-HPLC method for the determination of gliclazide in tablet dosage form

A new sensitive and economic analytical method for the analysis of gliclazide in tablet dosage form was developed and validated using commercial HPLC instrument with modern ultra-performance liquid chromatography column. Samples were analysed using Agilent 1100 Series RP-HPLC equipped with a binary pump and auto injector. Samples were injected into Xselect HSS C18 XP column (2.1 × 100 mm, 2.5 μm), 2.5 μm) and the mobile phase consisted of triethylamine buffer 0.3% (pH = 3 adjusted using phosphoric acid) and acetonitrile in the ratio of 50:50 v/v. The flow rate was 0.4 mL/min and the DAD detector was used for the detection and the wavelength was 229 nm. The method was validated according to ICH guidelines. The retention time for gliclazide peak was 3.437 ± 0.41 min with the total run time of 6 min with total solvent consumption of 2.4 mL per run. The method was found linear over the range 0.1-10 μg/mL with coefficient of determination R² of 0.9997. The recovery was 98.09-100.19 %, and the method showed high precision and repeatability. Degradation pathway of gliclazide was studied following different types of stress degradation which are base, acid, UV, and oxidization. All validated parameters were in the acceptable range of ICH requirements. In conclusion, a new, rapid, sensitive, and economic method was developed and validated for the analysis of gliclazide in tablet dosage form. © 2017, Colegio de Farmaceuticos de la Provincia de Buenos Aires. All rights reserved.

品名

编号

XSelect HSS C18 SB Column, 100Å, 3.5 µm,  2.1 mm X 50 mm, 1/pkg

186006422

XSelect HSS C18 SB Column, 100Å, 3.5 µm,  2.1 mm X 30 mm, 1/pkg

186006421

XSelect HSS C18 SB Column, 100Å, 3.5 µm,  2.1 mm X 100 mm, 1/pkg

186006424

XSelect HSS C18 SB Column, 100Å, 3.5 µm,  2.1 mm X 75 mm, 1/pkg

186006423

XSelect HSS C18 SB Column, 100Å, 3.5 µm,  2.1 mm X 150 mm, 1/pkg

186006425

XSelect HSS C18 SB Column, 100Å, 3.5 µm,  4.6 mm X 75 mm, 1/pkg

186006428

XSelect HSS C18 SB Column, 100Å, 3.5 µm,  4.6 mm X 50 mm, 1/pkg

186004753

XSelect HSS C18 SB Column, 100Å, 5 µm,  2.1 mm X 150 mm, 1/pkg

186006434

XSelect HSS C18 SB Column, 100Å, 5 µm,  2.1 mm X 100 mm, 1/pkg

186006433

XSelect HSS C18 SB Column, 100Å, 5 µm, 1  mm X 150 mm, 1/pkg

186006419

XSelect HSS C18 SB Column, 100Å, 3.5 µm,  3 mm X 150 mm, 1/pkg

186004744

XSelect HSS C18 SB Column, 100Å, 3.5 µm,  3 mm X 100 mm, 1/pkg

186004743

XSelect HSS C18 SB Column, 100Å, 3.5 µm,  4.6 mm X 150 mm, 1/pkg

186004749

XSelect HSS C18 SB Column, 100Å, 3.5 µm,  4.6 mm X 30 mm, 1/pkg

186004752

XSelect HSS C18 SB Column, 100Å, 3.5 µm,  4.6 mm X 100 mm, 1/pkg

186004748

XSelect HSS C18 SB Column, 100Å, 3.5 µm,  4.6 mm X 250 mm, 1/pkg

186004751

XSelect HSS C18 SB Column, 100Å, 3.5 µm,  3 mm X 50 mm, 1/pkg

186004747

XSelect HSS C18 SB Column, 100Å, 3.5 µm,  3 mm X 30 mm, 1/pkg

186004746

XSelect HSS C18 SB Column, 100Å, 5 µm, 3  mm X 250 mm, 1/pkg

186006440

XSelect HSS C18 SB Column, 100Å, 5 µm,  4.6 mm X 30 mm, 1/pkg

186006442

XSelect HSS C18 SB Column, 100Å, 5 µm,  4.6 mm X 100 mm, 1/pkg

186006444

XSelect HSS C18 SB Column, 100Å, 5 µm,  4.6 mm X 75 mm, 1/pkg

186006443

XSelect HSS C18 SB Column, 100Å, 5 µm,  4.6 mm X 250 mm, 1/pkg

186004756

XSelect HSS C18 SB Column, 100Å, 5 µm,  4.6 mm X 150 mm, 1/pkg

186004754

XSelect HSS C18 SB Column, 100Å, 5 µm,  4.6 mm X 50 mm, 1/pkg

186004757

XSelect HSS C18 SB Column, 100Å, 5 µm,  2.1 mm X 30 mm, 1/pkg

186006431

XSelect HSS C18 SB Column, 100Å, 5 µm,  2.1 mm X 50 mm, 1/pkg

186006432

XSelect HSS C18 SB Column, 100Å, 5 µm, 3  mm X 100 mm, 1/pkg

186006438

XSelect HSS C18 SB Column, 100Å, 5 µm, 3  mm X 150 mm, 1/pkg

186006439

XSelect HSS C18 SB Column, 100Å, 5 µm, 3  mm X 50 mm, 1/pkg

186006437


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