因其所带来的峰对称性、柱效和化学稳定性，1.7 μm ACQUITY UPLC BEH C18和C8柱是广泛适用于各种分析物通用的超高效色谱分离柱。因能在pH 1-12范围内操作，这些三键键合式烷基柱能够利用宽pH调节对可离子化化合物的保留、选择和灵敏度施加巨大影响，同时还能在低pH和高pH条件下保持优异的柱稳定性。
Stability indicating UPLC method for simultaneous determination of atorvastatin, fenofibrate and their degradation products in tablets
A stability indicating UPLC method was developed and validated for the simultaneous determination of atorvastatin, fenofibrate and their impurities in tablets. The chromatographic separation was performed on acquity UPLC BEH C18 column (1.7 μm, 2.1 mm × 100 mm) using gradient elution of acetonitrile and ammonium acetate buffer (pH 4.7; 0.01 M) at flow rate of 0.5 ml/min. UV detection was performed at 247 nm. Total run time was 3 min within which main compounds and six other known and major unknown impurities were separated. Stability indicating capability was established by forced degradation experiments and separation of known degradation products. The method was validated for accuracy, repeatability, reproducibility and robustness. Linearity, LOD and LOQ was established for atorvastatin, fenofibrate and their known impurities.
品名 | 编号 |
ACQUITY - XBridge BEH C18 Method Transfer Kit, 130Å, 1.7 - 3.5 µm, 2.1 - 4.6 mm X 50 - 100mm, 2/p... | 186004964 |
ACQUITY - XBridge BEH C18 Method Transfer Kit, 130Å, 1.7 - 5 µm, 2.1 - 4.6 mm X 50 - 150mm, 2/pkg | 186004958 |
ACQUITY - XBridge BEH C18 Method Transfer Kit, 130Å, 1.7 - 3.5 µm, 2.1 - 4.6 mm X 100 - 150mm, 2/... | 186004971 |
ACQUITY PREMIER BEH C18 Column, 1.7 µm, 2.1 x 50 mm, 1/pk | 186009452 |
ACQUITY PREMIER BEH C18 Column with VanGuard FIT, 1.7 µm, 2.1 x 50 mm, 1/pk | 186009455 |
ACQUITY PREMIER BEH C18 Column, 1.7 µm, 2.1 x 100 mm, 1/pk | 186009453 |
ACQUITY PREMIER BEH C18 Column, 1.7 µm, 2.1 x 150 mm, 1/pk | 186009454 |
ACQUITY PREMIER BEH C18 VanGuard FIT Cartridge, 1.7 µm, 2.1 x 5 mm, 3/pk | 186009459 |
ACQUITY PREMIER BEH C18 Column with VanGuard FIT, 1.7 µm, 2.1 x 100 mm, 1/pk | 186009457 |
ACQUITY PREMIER BEH C18 Column with VanGuard FIT, 1.7 µm, 2.1 x 150 mm, 1/pk | 186009458 |
ACQUITY PREMIER Peptide BEH C18 Column, 300Å, 1.7 µm, 2.1 x 100 mm, 1/pk | 186009494 |
ACQUITY PREMIER Peptide BEH C18 Column, 300Å, 1.7 µm, 2.1 x 50 mm, 1/pk | 186009493 |
ACQUITY PREMIER Peptide BEH C18 Column, 300Å, 1.7 µm, 2.1 x 150 mm, 1/pk | 186009495 |
ACQUITY PREMIER Peptide BEH C18 Column, 130Å, 1.7 µm, 2.1 x 50 mm, 1/pk | 186009481 |
ACQUITY PREMIER Peptide BEH C18 Column, 130Å, 1.7 µm, 2.1 x 150 mm, 1/pk | 186009483 |
ACQUITY PREMIER Peptide BEH C18 Column, 130Å, 1.7 µm, 2.1 x 100 mm, 1/pk | 186009482 |
ACQUITY UPLC BEH C18 Column, 130Å, 1.7 µm, 1 mm X 150 mm, 3/pkg | 176001044 |
ACQUITY UPLC BEH C18 Column, 130Å, 1.7 µm, 3 mm X 100 mm, 1/pkg | 186004661 |
ACQUITY UPLC BEH C18 Column, 130Å, 1.7 µm, 2.1 mm X 150 mm, 3/pkg | 176001048 |
ACQUITY UPLC BEH C18 Column, 130Å, 1.7 µm, 3 mm X 50 mm, 1/pkg | 186004660 |
ACQUITY UPLC BEH C18 Column, 130Å, 1.7 µm, 2.1 mm X 150 mm, 1/pkg | 186002353 |
ACQUITY UPLC BEH C18 Column, 130Å, 1.7 µm, 2.1 mm X 100 mm, 1/pkg | 186002352 |
ACQUITY UPLC BEH C18 Column, 130Å, 1.7 µm, 2.1 mm X 50 mm, 1/pkg | 186002350 |
ACQUITY UPLC BEH C18 Column, 130Å, 1.7 µm, 1 mm X 50 mm, 1/pkg | 186002344 |
ACQUITY UPLC BEH C18 Column, 130Å, 1.7 µm, 1 mm X 100 mm, 3/pkg | 176000862 |
ACQUITY UPLC BEH C18 Column, 130Å, 1.7 µm, 2.1 mm X 50 mm, 3/pkg | 176000863 |
ACQUITY UPLC BEH C18 Column, 130Å, 1.7 µm, 1 mm X 100 mm, 1/pkg | 186002346 |
ACQUITY UPLC BEH C18 Column, 130Å, 1.7 µm, 2.1 mm X 100 mm, 3/pkg | 176000864 |
ACQUITY UPLC BEH C18 Column, 130Å, 1.7 µm, 1 mm X 150 mm, 1/pkg | 186002347 |
ACQUITY UPLC BEH C18 Column, 130Å, 1.7 µm, 2.1 mm X 30 mm, 1/pkg | 186002349 |
ACQUITY UPLC BEH C18 Column, 130Å, 1.7 µm, 1 mm X 50 mm, 3/pkg | 176000861 |
ACQUITY UPLC BEH C18 Column, 130Å, 1.7 µm, 3 mm X 30 mm, 1/pkg | 186004659 |
ACQUITY UPLC BEH C18 Column, 130Å, 1.7 µm, 3 mm X 100 mm, 3/pkg | 176001796 |
ACQUITY UPLC BEH C18 Column, 130Å, 1.7 µm, 3 mm X 30 mm, 3/pkg | 176001794 |
ACQUITY UPLC BEH C18 Column, 130Å, 1.7 µm, 2.1 mm X 30 mm, 3/pkg | 176001304 |
ACQUITY UPLC BEH C18 Column, 130Å, 1.7 µm, 3 mm X 150 mm, 3/pkg | 176001797 |
ACQUITY UPLC BEH C18 Column, 130Å, 1.7 µm, 3 mm X 150 mm, 1/pkg | 186004690 |
ACQUITY UPLC BEH C18 Column, 130Å, 1.7 µm, 3 mm X 75 mm, 1/pkg | 186005609 |
ACQUITY UPLC BEH C18 Method Validation Kit, 130Å, 1.7 µm, 2.1 mm X 100 mm, 3/pkg | 186004045 |
ACQUITY UPLC BEH C18 Method Validation Kit, 130Å, 1.7 µm, 2.1 mm X 50 mm, 3/pkg | 186004044 |
ACQUITY UPLC BEH C18 Method Validation Kit, 130Å, 1.7 µm, 2.1 mm X 150 mm, 3/pkg | 186006019 |
ACQUITY UPLC BEH C18 Column, 130Å, 1.7 µm, 3 mm X 50 mm, 3/pkg | 176001795 |
ACQUITY UPLC BEH C18 VanGuard Pre-column, 130Å, 1.7 µm, 2.1 mm X 5 mm, 3/pkg | 186003975 |
ACQUITY UPLC BEH C18 Method Validation Kit, 130Å, 1.7 µm, 3 mm X 100 mm, 3/pkg | 186004692 |
ACQUITY UPLC BEH C18 Method Validation Kit, 130Å, 1.7 µm, 3 mm X 50 mm, 3/pkg | 186004691 |
ACQUITY UPLC Oligonucleotide BEH C18 Column, 130Å, 1.7 µm, 2.1 mm X 100 mm, 1/pkg | 186003950 |
ACQUITY UPLC Peptide BEH C18 Column, 300Å, 1.7 µm, 2.1 mm X 100 mm, 1/pkg | 186003686 |
ACQUITY UPLC Peptide BEH C18 Column, 300Å, 1.7 µm, 2.1 mm X 150 mm, 1/pkg | 186003687 |
ACQUITY UPLC Peptide BEH C18 Column, 300Å, 1.7 µm, 2.1 mm X 50 mm, 1/pkg | 186003685 |
ACQUITY UPLC Oligonucleotide BEH C18 Method Validation Kit, 130Å, 1.7 µm, 2.1 mm X 100 mm, 3/pkg | 186004898 |
ACQUITY UPLC Oligonucleotide BEH C18 Column, 130Å, 1.7 µm, 2.1 mm X 50 mm, 1/pkg | 186003949 |
ACQUITY UPLC Peptide BEH C18 Method Validation Kit, 300Å, 1.7 µm, 2.1 mm X 100 mm, 3/pkg | 186004897 |
ACQUITY UPLC Peptide BEH C18 Method Validation Kit, 130Å, 1.7 µm, 2.1 mm X 100 mm, 3/pkg | 186004896 |
ACQUITY UPLC Peptide BEH C18 Column, 130Å, 1.7 µm, 2.1 mm X 50 mm, 1/pkg | 186003554 |
ACQUITY UPLC Peptide BEH C18 Column, 300Å, 1.7 µm, 1 mm X 50 mm, 1/pkg | 186005592 |
ACQUITY UPLC Peptide BEH C18 Column, 130Å, 1.7 µm, 2.1 mm X 100 mm, 1/pkg | 186003555 |
ACQUITY UPLC Peptide BEH C18 Column, 300Å, 1.7 µm, 1 mm X 100 mm, 1/pkg | 186005593 |
ACQUITY UPLC Peptide BEH C18 Column, 130Å, 1.7 µm, 2.1 mm X 150 mm, 1/pkg | 186003556 |
ACQUITY UPLC Peptide BEH C18 Method Validation Kit, 130Å, 1.7 µm, 2.1 mm X 150 mm, 3/pkg | 186006516 |
ACQUITY UPLC Peptide BEH C18 Column, 300Å, 1.7 µm, 1 mm X 150 mm, 1/pkg | 186005594 |
ACQUITY UPLC Peptide BEH C18 Method Validation Kit, 300Å, 1.7 µm, 2.1 mm X 150 mm, 3/pkg | 186006517 |
ACQUITY UPLC Oligonucleotide BEH C18 Column, 130Å, 1.7 µm, 2.1 mm X 150 mm, 1/pkg | 186005516 |
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