基于第一代杂化颗粒技术的 XTerra® 系列高效液相色谱柱, 可以让色谱工作者在药物发现，方法开发和纯化分离领域使用高pH值流动相。
§ XTerra颗粒能耐受二甲基亚砜（DMSO）溶剂，可延长高通量药物发现研究中色谱柱的寿命。
§ 宽pH 范围使得方法开发研究人员在所需的pH值条件下操作，以获得好的选择性。
§ 高载荷量使得分离纯化的科学家在高pH值条件下，在纯化碱性化合物时，一次进样量增加六十倍。
XTerra® MS、Shield RP和苯基色谱柱将硅胶和聚合物键合相的最 佳性能与专利的杂化颗粒技术相结合，在颗粒合成中每三个硅 烷醇中有一个被替换成甲基基团。这个步骤只能在颗粒合成的 起始阶段完成，加入的此甲基基团是碱性颗粒骨架的组成部分。 由此可生成机械强度大的颗粒，适用于高pH值条件下的分离，提 高碱性化合物的上样量和峰形。
XTerra® RP18和RP8色谱柱将内嵌极性基团的屏蔽技术与杂化颗粒技术结合起来，可以获得对称的色谱峰形。这一通用型色谱柱以独特的选择性为快速方法开发提供了一个强有力的工具。同其它所有XTerra® 色谱柱一样，利用屏蔽技术的XTerra® RP色谱柱展现了极其优秀的水浸润性，即便是使用100%的水溶液作为流动相，亦可获得稳定的色谱结果。大大拓宽的pH范围，为选择性调节提供了有效途径；加上选择性互补的MS和RP两种键合相更是增加了选择性的调节范围，是成功进行方法开发的工具。
A simple method is presented for the simultaneous determination of morphine, 6-acetylmorphine, codeine, cocaine, benzoylecgonine, cocaethylene, methadone and 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) in vitreous humor by high-performance liquid chromatography with photodiode array detector after solid-phase extraction with Oasis® HLB cartridges and dichloromethane as eluent. The chromatographic process was carried out using an XTerra® RP8 column (250 × 4.6 mm i.d., 5 µm particle size) and a mobile phase composed of acetonitrile and pH 6.5 phosphate buffer in gradient mode. A linear response from the detector was obtained within the concentration range of 0.1-4 µg ml(-1) , with correlation coefficients higher than 0.99. The limits of detection were lower than 30 ng ml(-1) for all the drugs studied, the coefficients of variation fluctuated between 0.1 and 12.4%, and the average recoveries were higher than 78% for all the drugs except for EDDP, with a value of 66.4%. Finally, the proposed method was applied to 15 vitreous humor samples coming from individuals who had died from opiate and/or cocaine overdose, showing consumption of cocaine in 14 cases, methadone in five cases and heroin in three cases. Average concentrations of 0.30 µg ml(-1) for morphine, 0.24 µg ml(-1) for 6-acetylmorphine, 0.10 µg ml(-1) for codeine, 0.81 µg ml(-1) for cocaine, 1.26 µg ml(-1) for benzoylecgonine, 0.15 µg ml(-1) for cocaethylene, 0.11 µg ml(-1) for methadone and 0.68 µg ml(-1) for EDDP were obtained.
| 品名 | 编号 |
| XTerra RP 8 OBD Prep Column, 125Å, 10 µm, 19 mm X 150 mm, 1/pkg | 186002258 |
| XTerra RP 8 Column, 125Å, 5 µm, 4.6 mm X 150 mm, 1/pkg | 186000493 |
| XTerra RP 8 Column, 125Å, 5 µm, 3 mm X 150 mm, 1/pkg | 186000473 |
| XTerra RP 8 OBD Prep Column, 125Å, 10 µm, 30 mm X 300 mm, 1/pkg | 186002278 |
| XTerra RP 8 OBD Prep Column, 125Å, 10 µm, 50 mm X 250 mm, 1/pkg | 186002850 |
| XTerra RP 8 Column, 125Å, 5 µm, 2.1 mm X 150 mm, 1/pkg | 186000457 |
| XTerra RP 8 OBD Prep Column, 125Å, 5 µm, 30 mm X 100 mm, 1/pkg | 186001945 |
| XTerra RP 8 Column, 125Å, 5 µm, 2.1 mm X 100 mm, 1/pkg | 186000453 |
| XTerra RP 8 Column, 125Å, 3.5 µm, 4.6 mm X 50 mm, 1/pkg | 186000435 |
| XTerra RP 8 OBD Prep Column, 125Å, 10 µm, 30 mm X 250 mm, 1/pkg | 186002274 |
| XTerra RP 8 OBD Prep Column, 125Å, 10 µm, 30 mm X 150 mm, 1/pkg | 186002270 |
| XTerra RP 8 Column, 125Å, 5 µm, 4.6 mm X 30 mm, 1/pkg | 186001911 |
| XTerra RP 8 Column, 125Å, 5 µm, 4.6 mm X 250 mm, 1/pkg | 186000497 |
| XTerra RP 8 Column, 125Å, 5 µm, 3.9 mm X 150 mm, 1/pkg | 186000481 |
| XTerra RP 8 Column, 125Å, 5 µm, 2.1 mm X 250 mm, 1/pkg | 186000461 |
| XTerra RP 8 OBD Prep Column, 125Å, 5 µm, 19 mm X 100 mm, 1/pkg | 186001937 |
| XTerra RP 8 OBD Prep Column, 125Å, 5 µm, 19 mm X 150 mm, 1/pkg | 186002382 |
| XTerra RP 8 Column, 125Å, 5 µm, 3 mm X 100 mm, 1/pkg | 186000469 |
| XTerra RP 8 OBD Prep Column, 125Å, 10 µm, 50 mm X 150 mm, 1/pkg | 186002846 |
| XTerra RP 8 Column, 125Å, 5 µm, 4.6 mm X 50 mm, 1/pkg | 186000485 |
| XTerra RP 8 Column, 125Å, 5 µm, 2.1 mm X 50 mm, 1/pkg | 186000449 |
| XTerra RP 8 OBD Prep Column, 125Å, 10 µm, 19 mm X 250 mm, 1/pkg | 186002262 |
| XTerra RP 8 Column, 125Å, 5 µm, 4.6 mm X 100 mm, 1/pkg | 186000489 |
| XTerra RP 8 OBD Prep Column, 125Å, 10 µm, 50 mm X 50 mm, 1/pkg | 186002282 |
| XTerra RP 8 OBD Prep Column, 125Å, 10 µm, 19 mm X 300 mm, 1/pkg | 186002266 |
| XTerra RP 8 Prep Guard Cartridge, 125Å, 5 µm, 19 mm X 10 mm, 1/pkg | 186001107 |
| XTerra RP 8 Prep Guard Cartridge, 125Å, 10 µm, 19 mm X 10 mm, 1/pkg | 186001037 |
| XTerra RP 8 Prep Column, 125Å, 5 µm, 7.8 mm X 50 mm, 1/pkg | 186001155 |
| XTerra RP 8 Prep Guard Cartridge, 125Å, 10 µm, 7.8 mm X 10 mm, 1/pkg | 186001175 |
| XTerra RP 8 Prep Guard Cartridge, 125Å, 5 µm, 7.8 mm X 10 mm, 1/pkg | 186001171 |
| XTerra Shield RP18 Column, 125Å, 3.5 µm, 2.1 mm X 150 mm, 1/pkg | 186000410 |
| XTerra Shield RP18 Column, 125Å, 3.5 µm, 2.1 mm X 20 mm, 1/pkg | 186001925 |
| XTerra RP18 Prep Guard Cartridge, 125Å, 10 µm, 30 mm X 10 mm, 1/pkg | 186006905 |
| XTerra RP18 Prep Guard Cartridge, 125Å, 5 µm, 30 mm X 10 mm, 1/pkg | 186006906 |
| XTerra RP 8 OBD Prep Column, 125Å, 5 µm, 30 mm X 50 mm, 1/pkg | 186001941 |
| XTerra RP 8 OBD Prep Column, 125Å, 5 µm, 30 mm X 75 mm, 1/pkg | 186002390 |
| XTerra RP 8 Prep Column, 125Å, 5 µm, 7.8 mm X 100 mm, 1/pkg | 186001159 |
| XTerra RP 8 Prep Column, 125Å, 5 µm, 7.8 mm X 150 mm, 1/pkg | 186001478 |
| XTerra RP 8 Prep Guard Cartridge, 125Å, 10 µm, 10 mm X 10 mm, 1/pkg | 186001009 |
| XTerra Shield RP18 Cartridge, 125Å, 5 µm, 4.6 mm X 150 mm, 1/pkg | 186000580 |
| XTerra RP 8 Prep Guard Cartridge, 125Å, 5 µm, 10 mm X 10 mm, 1/pkg | 186001008 |
| XTerra Shield RP18 Column, 125Å, 3.5 µm, 2.1 mm X 100 mm, 1/pkg | 186000406 |
| XTerra Shield RP 8 VanGuard Cartridge, 125Å, 5 µm, 3.9 mm X 5 mm, 3/pkg | 186007947 |
| XTerra Shield RP 8 VanGuard Cartridge, 125Å, 5 µm, 2.1 mm X 5 mm, 3/pkg | 186007945 |
| XTerra Shield RP 8 VanGuard Cartridge, 125Å, 3.5 µm, 3.9 mm X 5 mm, 3/pkg | 186007943 |
| XTerra RP 8 OBD Prep Column, 125Å, 5 µm, 50 mm X 100 mm, 1/pkg | 186002225 |
| XTerra RP 8 Prep Column, 125Å, 10 µm, 7.8 mm X 150 mm, 1/pkg | 186001163 |
| XTerra RP 8 Prep Column, 125Å, 10 µm, 7.8 mm X 300 mm, 1/pkg | 186001167 |
| XTerra RP 8 OBD Prep Column, 125Å, 5 µm, 50 mm X 50 mm, 1/pkg | 186002221 |
| XTerra Shield RP 8 VanGuard Cartridge, 125Å, 3.5 µm, 2.1 mm X 5 mm, 3/pkg | 186007941 |
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